Can we ever expect to understand existence?

John Archibald Wheeler who, in his ‘It from bit’ talk concluded:

Can we ever expect to understand existence? Clues we have, and work to do, to make headway on that issue. Surely someday, we can believe, we will grasp the central idea of it all as so simple, so beautiful, so compelling that we will all say to each other, “Oh, how — could it have been otherwise! How could we all have been so blind so long!”